NSABP C-08: A Phase III Clinical Trial Comparing Infusional 5-FU, Leucovorin, and Oxaliplatin, Every Two Weeks with Bevacizumab to the Same Regimen without Bevacizumab for the Treatment of the Patients with Resected Stages II and III Carcinoma of the Colon.
Principal Investigator: Robert J. Gottlieb, MD
Collaborators: G/ Thomas O’Conor, MD; Ashok Beedassy, MD; Shyam Balepur, MD; Elizabeth Horenkamp, MD
Sponsor: NSABP
Objective: This phase III study will evaluate the relative efficacy of infusional-5FU, Leucovorin, and Oxaliplatin alone or the same chemotherapy regimen with Bevacizumab in patients with resected Stage II and III carcinoma of the colon. The primary goal of the study is to determine whether disease-free survival can be improved by the addition of Bevacizumab to the modified FOLFOX6 regimen. Other goals are to compare the relative efficacy of the two regimens in prolonging survival and to evaluate adverse events related to Bevacizumab.
A Prospective, Multicenter, Controlled Clinical Trial of an Artificial Cervical Disc-LP at a Single Level for Symptomatic Cervical Disc Disease
Principal Investigator: Perry J. Argires, MD
Collaborators: None
Sponsor: Medtronic
Objective: Treatment of single level disc disease with new low profile design of on going Prestige study.
BiVentricular Epicardial Pacing in High Risk Cardiac Surgery Patients
Principal Investigator: Edward Lundy, MD
Collaborators: Douglas Gohn, MD; Seth Worley, MD; Jeffrey Cope, MD; Mark Burlingame, MD; Roy Small, MD; Jill Repoley, MSN, CRNP; Susan Sample, MSN, CRNP
Sponsor: None
Objective: Current practice in cardiac surgery is to place temporary epicardial pacemaker wires in patients to provide a back-up safety mechanism while the heart recovers from surgery. The standard of care is to place ventricular leads in the right ventricle only. In heart failure patients, this can exacerbate the cardiac disynchrony that we commonly see in an enlarged heart. With the proven therapeutic response of heart failure patients to biventricular pacing, we have hypothesized that biventricular epicardial pacing in the peri-operative period will increase cardiac output and potentially decrease use of inotropes. This can therefore improve patient outcomes as well as decrease hospital length of stay.
Primary Objectives:
1. To determine if there is improvement in cardiac output in patients with biventricular epicardial pacing in the peri-operative setting.
2. To determine if there is a decreased need for inotropes in the post-operative heart failure patient with use of biventricular pacing
Secondary Objective:
1. To determine if biventricular epicardial pacing can decrease the length of stay in high risk surgical patients.